[HTML][HTML] TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease
Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling
has fundamental roles in both embryonic skeletal development and postnatal bone …
has fundamental roles in both embryonic skeletal development and postnatal bone …
BMP signalling in skeletal development, disease and repair
VS Salazar, LW Gamer, V Rosen - Nature Reviews Endocrinology, 2016 - nature.com
Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …
of bone and cartilage formation, BMP superfamily signalling has become one of the most …
TGFβ signaling in cartilage development and maintenance
Members of the transforming growth factor beta (TGFβ) superfamily of secreted factors play
essential roles in nearly every aspect of cartilage formation and maintenance. However, the …
essential roles in nearly every aspect of cartilage formation and maintenance. However, the …
[HTML][HTML] Genesis and morphogenesis of limb synovial joints and articular cartilage
RS Decker, E Koyama, M Pacifici - Matrix Biology, 2014 - Elsevier
Limb synovial joints are intricate structures composed of articular cartilage, synovial
membranes, ligaments and an articular capsule. Together, these tissues give each joint its …
membranes, ligaments and an articular capsule. Together, these tissues give each joint its …
[HTML][HTML] Post-transcriptional regulatory crosstalk between MicroRNAs and canonical TGF-β/BMP signalling cascades on osteoblast lineage: a comprehensive review
HY Loh, BP Norman, KS Lai, WH Cheng… - International journal of …, 2023 - mdpi.com
MicroRNAs (miRNAs) are a family of small, single-stranded, and non-protein coding RNAs
about 19 to 22 nucleotides in length, that have been reported to have important roles in the …
about 19 to 22 nucleotides in length, that have been reported to have important roles in the …
Exercise decreases marrow adipose tissue through ß‐oxidation in obese running mice
The relationship between marrow adipose tissue (MAT) and bone health is poorly
understood. We used running exercise to ask whether obesity‐associated MAT can be …
understood. We used running exercise to ask whether obesity‐associated MAT can be …
Cartilage regeneration for treatment of osteoarthritis: a paradigm for nonsurgical intervention
ML Tiku, HE Sabaawy - Therapeutic advances in …, 2015 - journals.sagepub.com
Osteoarthritis (OA) is associated with articular cartilage abnormalities and affects people of
older age: preventative or therapeutic treatment measures for OA and related articular …
older age: preventative or therapeutic treatment measures for OA and related articular …
A homeostatic function of CXCR2 signalling in articular cartilage
Objective ELR+ CXC chemokines are heparin-binding cytokines signalling through the
CXCR1 and CXCR2 receptors. ELR+ CXC chemokines have been associated with …
CXCR1 and CXCR2 receptors. ELR+ CXC chemokines have been associated with …
[HTML][HTML] Role of the CC chemokine receptor-2 in a murine model of injury-induced osteoarthritis
L Longobardi, JD Temple, L Tagliafierro… - Osteoarthritis and …, 2017 - Elsevier
Objective We previously found in our embryonic studies that proper regulation of the
chemokine CCL12 through its sole receptor CCR2, is critical for joint and growth plate …
chemokine CCL12 through its sole receptor CCR2, is critical for joint and growth plate …
[HTML][HTML] The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …