Glycosphingolipids (GSL s) comprise a heterogeneous group of membrane lipids formed by
a ceramide backbone covalently linked to a glycan moiety. Hundreds of different glycans …

Gaucher disease (GD) is an autosomal recessive lysosomal storage disease, caused by
deficiency of the enzyme glucocerebrosidase, required for the degradation of …

The molecular repertoire promoting cancer cell plasticity is not fully elucidated. Here, we
propose that glycosphingolipids (GSLs), specifically the globo and ganglio series, correlate …

Drug resistance elicited by cancer cells still constitutes a huge problem that frequently
impairs the efficacy of both conventional and novel molecular therapies. Chemotherapy …

Glycosphingolipids (GSLs) are major amphiphilic glycolipids present on the surface of living
cell membranes. They have important biological functions, including maintaining plasma …

Glycosphingolipids (GSLs) are a class of ceramide-based glycolipids essential for embryo
development in mammals. The synthesis of specific GSLs depends on the expression of …

Every living cell is covered with a dense and complex layer of glycans on the cell surface,
which have important functions in the interaction between cells and their environment …

Non–small cell lung cancer (NSCLC), a major life-threatening disease accounting for 85% of
all lung cancer cases, has been treated with tyrosine kinase inhibitors (TKIs), but often …

Glycosphingolipids (GSLs) are ubiquitous components of eukaryotic plasma membranes
that consist of a ceramide backbone linked to a glycan moiety. Both the ceramide and the …

Glycosphingolipids are important components of the plasma membrane where they
modulate the activities of membrane proteins including signalling receptors …