Background and Objectives There is growing evidence for endovascular thrombectomy
(EVT) in patients with large ischemic core infarct and large vessel occlusion (LVO). The …

Stroke is a major cause of morbidity and mortality. Neurosurgical decompression is often
considered for the treatment of malignant infarcts and intraparenchymal hemorrhages, but …

Background The current research-care separation was introduced to protect patients from
explanatory studies designed to gain knowledge for future patients. Care trials are all …

Background The best management of basilar artery occlusion (BAO) remains uncertain. The
BASICS (Basilar Artery International Cooperation Study) and the BEST (Basilar Artery …

Introduction Uncertainty remains on the optimal management of basilar artery occlusion
(BAO). Two large randomized controlled trials (RCTs) in 2019 and 2021 demonstrated …

The explanatory/pragmatic-trial distinction enjoys a burgeoning philosophical and medical
literature and a significant contingent of support among philosophers and healthcare …

Most endovascular innovations have been introduced into clinical care by showing good
outcomes in small enthusiastic case series of selected patients. Randomized clinical trials …

Background: Termination of a clinical trial before the maximum planned sample size is
accrued can occur for multiple valid reasons but has implications for the interpretation of …

The temptation to use prospective observational studies (POS) instead of conducting difficult
trials (RCTs) has always existed, but with the advent of powerful computers and large …

The current separation between medical research and care is an obstacle to essential
aspects of good medical practice: the verification that care interventions actually deliver the …