It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype
that we have previously shown to be highly efficient for discovery of genetic associations …

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can
inform our understanding of the underlying biological mechanisms that influence adverse …

Clinical outcomes of severe acute respiratory syndrome 2 (SARS-CoV-2) infection are highly
heterogeneous, ranging from asymptomatic infection to lethal coronavirus disease 2019 …

LY6E is an antiviral restriction factor that inhibits coronavirus spike-mediated fusion, but the
cell types in vivo that require LY6E for protection from respiratory coronavirus infection are …

Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights
have been gained into virus biology and the host factors that modulate the human immune …

Mechanisms underpinning the dysfunctional immune response in severe acute respiratory
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …

Surviving long periods without food has shaped human evolution. In ancient and modern
societies, prolonged fasting was/is practiced by billions of people globally for religious …

Precision public health (PPH) considers the interplay between genetics, lifestyle and the
environment to improve disease prevention, diagnosis and treatment on a population level …