Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy

S Grisaru-Tal, ME Rothenberg, A Munitz - Nature immunology, 2022 - nature.com
Eosinophils are important effector cells and therapeutic targets in allergic diseases.
Emerging data indicate that eosinophils infiltrate a variety of solid tumor types and have …

Eosinophils from A to Z

L Gigon, T Fettrelet, S Yousefi, D Simon, HU Simon - Allergy, 2023 - Wiley Online Library
Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

[HTML][HTML] Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization

A Ignacio, K Shah, J Bernier-Latmani, Y Köller… - Immunity, 2022 - cell.com
The intestine harbors a large population of resident eosinophils, yet the function of intestinal
eosinophils has not been explored. Flow cytometry and whole-mount imaging identified …

The ins and outs of innate and adaptive type 2 immunity

AB Molofsky, RM Locksley - Immunity, 2023 - cell.com
Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease

IC Arnold, A Munitz - Nature Reviews Immunology, 2024 - nature.com
Eosinophils are bone marrow-derived granulocytes that are traditionally associated with
type 2 immune responses, such as those that occur during parasite infections and allergy …

The aryl hydrocarbon receptor contributes to tissue adaptation of intestinal eosinophils in mice

NL Diny, B Schonfeldova, M Shapiro… - Journal of Experimental …, 2022 - rupress.org
Eosinophils are potent sources of inflammatory and toxic mediators, yet they reside in large
numbers in the healthy intestine without causing tissue damage. We show here that …

Role of Innate Immunity in Allergic Contact Dermatitis: An Update

HL Yamaguchi, Y Yamaguchi, E Peeva - International Journal of …, 2023 - mdpi.com
Our understanding of allergic contact dermatitis mechanisms has progressed over the past
decade. Innate immune cells that are involved in the pathogenesis of allergic contact …

Emerging functions of tissue-resident eosinophils

A Gurtner, D Crepaz, IC Arnold - Journal of Experimental Medicine, 2023 - rupress.org
Eosinophils are typically considered tissue-damaging effector cells in type 2 immune-related
diseases. However, they are also increasingly recognized as important modulators of …

Stress-free single-cell transcriptomic profiling and functional genomics of murine eosinophils

C Borrelli, A Gurtner, IC Arnold, AE Moor - Nature Protocols, 2024 - nature.com
Eosinophils are a class of granulocytes with pleiotropic functions in homeostasis and
various human diseases. Nevertheless, they are absent from conventional single-cell RNA …

[HTML][HTML] Unveiling multifaceted roles of myeloid innate immune cells in the pathogenesis of psoriasis

S Park, J Jang, HJ Kim, YJ Jung - Molecular Aspects of Medicine, 2024 - Elsevier
Psoriasis is a chronic inflammatory skin disease occurring worldwide. Initially viewed as a
keratinocyte disorder, psoriasis is now recognized to involve a complex interplay between …