Patients with malignant melanoma generally have a good prognosis if the disease presents
prior to metastasis. Due to progress with targeted and immunotherapies, the median survival …

Histone variants are chromatin components that replace replication-coupled histones in a
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …

Summary The developmental disorder Floating-Harbor syndrome (FHS) is caused by
heterozygous truncating mutations in SRCAP, a gene encoding a chromatin remodeler …

Transcription start sites (TSS) in eukaryotes are characterized by a nucleosome-depleted
region (NDR), which appears to be flanked upstream and downstream by strongly …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable and devastating
malignant tumors. Epigenetic modifications such as DNA methylation and histone …

The dynamic evolution of chromatin state patterns during metastasis, their relationship with
bona fide genetic drivers, and their therapeutic vulnerabilities are not completely …

Cutaneous melanoma shows a high metastatic potential based on its ability to overcome the
immune system's control. The mechanisms activated for these functions vary extremely and …

Background Epigenetics research is progressing in basic, pre-clinical and clinical studies
using various model systems. Hence, updating the knowledge and integration of biological …

Background: Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
(LHPP) is a novel tumor suppressor. However, whether LHPP is effective to melanoma has …

Uncontrolled proliferation is a key feature of tumor progression and malignancy. This
suggests that cell-cycle related factors could be exploited as cancer biomarkers and that …