Abstract Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …

Neurodegenerative disorders are accompanied by neuronal degeneration and glial
dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors …

Physical activity has been found to aid the maintenance of health in the elderly. Exercise-
induced skeletal muscle contractions lead to the production and secretion of many small …

The regulation of energy homeostasis is controlled by the brain and, besides requiring high
amounts of energy, it relies on functional insulin/insulin‐like growth factor (IGF)‐1 signalling …

The mitochondrial calcium uniporter (MCU) is the main route of calcium (Ca2+) entry into
neuronal mitochondria. This channel has been linked to mitochondrial Ca2+ overload and …

The mitochondria are key organelles regulating vital processes in the eukaryote cell. A
decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and …

Insulin-like growth factor 1 (IGF-1) deficiency is an ultrarare syndromic human sensorineural
deafness. Accordingly, IGF-1 is essential for the postnatal maturation of the cochlea and the …

LncRNA (long non-coding RNA) H19 is a transcript of the H19 gene that is expressed during
embryogenesis. We previously discovered a role for circular lncRNA H19 in the onset and …

Although the effects of growth hormone (GH) therapy on spinocerebellar ataxia type 3
(SCA3) have been examined in transgenic SCA3 mice, it still poses a nonnegligible risk of …

Mitochondria are vital organelles in eukaryotic cells that control diverse physiological
processes related to energy production, calcium homeostasis, the generation of reactive …