Long noncoding RNA (lncRNA)-mediated competing endogenous RNA networks provide novel potential biomarkers and therapeutic targets for colorectal cancer

L Wang, KB Cho, Y Li, G Tao, Z Xie, B Guo - International journal of …, 2019 - mdpi.com
Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and
reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth …

The WNT/ROR pathway in cancer: from signaling to therapeutic intervention

K Menck, S Heinrichs, C Baden, A Bleckmann - Cells, 2021 - mdpi.com
The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …

Tyrosine kinase ROR1 as a target for anti-cancer therapies

Y Zhao, D Zhang, Y Guo, B Lu, ZJ Zhao, X Xu… - Frontiers in …, 2021 - frontiersin.org
Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is
overexpressed in many types of malignant tumors. Studies have demonstrated that it plays …

Nanodiagnosis and nanotreatment of colorectal cancer: An overview

M Barani, M Bilal, A Rahdar, R Arshad, A Kumar… - Journal of Nanoparticle …, 2021 - Springer
The most suitable strategy to improving the long-term viability of cancer patients and
overcoming the high morbidity and severity of cancer is the precise identification of particular …

A review on protein markers of exosome from different bio-resources and the antibodies used for characterization

F Deng, J Miller - Journal of Histotechnology, 2019 - Taylor & Francis
Exosomes are small membrane vesicles (ranging from 30 nm to 150 nm), secreted by
different cell types upon fusion of multivesicular bodies (MVB) to the cell plasma membrane …

The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment

P Lopez-Bergami, G Barbero - Cancer and Metastasis Reviews, 2020 - Springer
Wnt5a is the prototypical activator of the non-canonical Wnt pathways, and its
overexpression has been implicated in the progression of several tumor types by promoting …

The expansion of targetable biomarkers for CAR T cell therapy

MH Townsend, G Shrestha, RA Robison… - Journal of Experimental & …, 2018 - Springer
Biomarkers are an integral part of cancer management due to their use in risk assessment,
screening, differential diagnosis, prognosis, prediction of response to treatment, and …

Targeting receptor kinases in colorectal cancer

M García-Aranda, M Redondo - Cancers, 2019 - mdpi.com
Colorectal cancer is the third most common malignancy in men and the second most
common cancer in women. Despite the success of screening programs and the …

Atractylenolide II reverses the influence of lncRNA XIST/miR‐30a‐5p/ROR1 axis on chemo‐resistance of colorectal cancer cells

R Zhang, Z Wang, Q Yu, J Shen, W He… - Journal of Cellular …, 2019 - Wiley Online Library
This investigation was conducted to elucidate whether atractylenolide II could reverse the
role of lnc RNA XIST/miR‐30a‐5p/ROR 1 axis in modulating chemosensitivity of colorectal …

[HTML][HTML] Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition

DJ Flanagan, SA Woodcock, C Phillips, C Eagle… - Pharmacology & …, 2022 - Elsevier
Gastrointestinal cancers are responsible for more cancer deaths than any other system of
the body. This review summarises how Wnt pathway dysregulation contributes to the …