Principle role of the (pro) renin receptor system in cardiovascular and metabolic diseases: An update

M Zhu, X Yi, S Song, H Yang, J Yu, C Xu - Cellular Signalling, 2024 - Elsevier
Abstract (Pro) renin receptor (PRR), along with its soluble form, sPRR, functions not only as
a crucial activator of the local renin-angiotensin system but also engages with and activates …

Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure

NM Mathieu, EE Tan, JJ Reho, DT Brozoski… - …, 2024 - Am Heart Assoc
BACKGROUND: ANG (angiotensin II) elicits dipsogenic and pressor responses via
activation of the canonical Gαq (G-protein component of the AT1R [angiotensin type 1 …

Definitive Evidence for the Identification and Function of Renin-Expressing Cholinergic Neurons in the Nucleus Ambiguus

ÉM Fekete, J Gomez, M Ghobrial, K Kaminski… - …, 2025 - ahajournals.org
BACKGROUND: The importance of the brain renin-angiotensin system in cardiovascular
function is well accepted. However, not knowing the precise source of renin in the brain has …

Interaction of afferent renal nerve activity and IL-1R signaling in hypertension

DC Baumann - 2024 - search.proquest.com
Renal denervation was recently approved by the FDA for the treatment of hypertension, but
the mechanism by which it reduces blood pressure is unclear. Studies of patients who have …