Role of piRNA biogenesis and its neuronal function in the development of neurodegenerative diseases

K Sato, K Takayama, S Inoue - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
and amyotrophic lateral sclerosis (ALS), are caused by neuronal loss and dysfunction …

Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases

Z Wu, X Yu, S Zhang, Y He, W Guo - Cell Communication and Signaling, 2023 - Springer
Non-coding RNA has aroused great research interest recently, they play a wide range of
biological functions, such as regulating cell cycle, cell proliferation, and intracellular …

iPiDA-GCN: Identification of piRNA-disease associations based on Graph Convolutional Network

J Hou, H Wei, B Liu - PLOS Computational Biology, 2022 - journals.plos.org
Motivation Piwi-interacting RNAs (piRNAs) play a critical role in the progression of various
diseases. Accurately identifying the associations between piRNAs and diseases is important …

NPInter v5. 0: ncRNA interaction database in a new era

Y Zheng, H Luo, X Teng, X Hao, X Yan… - Nucleic acids …, 2023 - academic.oup.com
Noncoding RNAs (ncRNAs) play key regulatory roles in biological processes by interacting
with other biomolecules. With the development of high-throughput sequencing and …

An ontology-based knowledge graph for representing interactions involving RNA molecules

E Cavalleri, A Cabri, M Soto-Gomez, S Bonfitto… - Scientific Data, 2024 - nature.com
The “RNA world” represents a novel frontier for the study of fundamental biological
processes and human diseases and is paving the way for the development of new drugs …

Paternal immune activation by poly I: C modulates sperm noncoding RNA profiles and causes transgenerational changes in offspring behavior

EA Kleeman, SN Reisinger, P Adithya… - Brain, Behavior, and …, 2024 - Elsevier
Paternal pre-conceptual environmental experiences, such as stress and diet, can affect
offspring brain and behavioral phenotypes via epigenetic modifications in sperm …

Depletion of the paternal gut microbiome alters sperm small RNAs and impacts offspring physiology and behavior in mice

BA Masson, P Kiridena, D Lu, EA Kleeman… - Brain, Behavior, and …, 2025 - Elsevier
The paternal environment prior to conception has been demonstrated to influence offspring
physiology and behavior, with the sperm epigenome (including noncoding RNAs) proposed …

RNAenrich: a web server for non-coding RNA enrichment

S Zhang, K Amahong, Y Zhang, X Hu, S Huang… - …, 2023 - academic.oup.com
Motivation With the rapid advances of RNA sequencing and microarray technologies in non-
coding RNA (ncRNA) research, functional tools that perform enrichment analysis for ncRNAs …

Decoding the non-coding: tools and databases unveiling the hidden world of “junk” RNAs for innovative therapeutic exploration

U Chaudhary, S Banerjee - ACS Pharmacology & Translational …, 2024 - ACS Publications
Non-coding RNAs are pivotal regulators of gene and protein expression, exerting crucial
influences on diverse biological processes. Their dysregulation is frequently implicated in …

piR-823 tale as emerging cancer-hallmark molecular marker in different cancer types: a step-toward ncRNA-precision

FH Shaker, EF Sanad, H Elghazaly, SM Hsia… - Naunyn-Schmiedeberg's …, 2024 - Springer
PIWI-interacting RNAs (piRNAs) have received a lot of attention for their functions in cancer
research. This class of short non-coding RNAs (ncRNA) has roles in genomic stability …