With recent advances in digitisation and big data analytics, more pharmaceutical firms are
adopting digital tools to achieve modernisation. The biological phenomena within …

With the continuous development, in the last decades, of analytical techniques providing
complex information at single cell level, the study of cell heterogeneity has been the focus of …

In this work, we focus on the development and application of predictive-based strategies for
control of particle size distribution (PSD) in continuous and batch particulate processes …

An efficient and novel solution technique is presented for solving multi-dimensional
population balance models. In addition to overcoming stiffness in the original system, the …

In the present article, recent developments on modeling and optimization of particulate
polymerization processes are reviewed. A unified population balance approach is described …

Microbial cultures are comprised of heterogeneous cells that differ according to their size
and intracellular concentrations of DNA, proteins and other constituents. Recent advances …

Mammalian cell cultures represent the major source for a number of very high-value
biopharmaceutical products, including monoclonal antibodies (MAbs), viral vaccines, and …

Several Galerkin, Tau and Collocation (pseudospectral) approximations have been
developed for the solution of the multi-variable cell population balance model in its most …

Heterogeneity among individual cells is a characteristic and relevant feature of living
systems. A range of experimental techniques to investigate this heterogeneity is available …

We have developed finite element approximations to the generalized multi-variable cell
population balance problem under conditions of changing substrate concentration. We …