Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …

The post-translational modification of proteins regulates many biological processes. Their
dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications …

The protein ubiquitin is a covalent modifier of proteins, including itself. The ubiquitin system
encompasses the enzymes required for catalysing attachment of ubiquitin to substrates as …

The clinical development of an inhibitor of cellular proteasome function suggests that
compounds targeting other components of the ubiquitin–proteasome system might prove …

NAMD is a parallel molecular dynamics code designed for high‐performance simulation of
large biomolecular systems. NAMD scales to hundreds of processors on high‐end parallel …

▪ Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …

Attachment of ubiquitin or ubiquitin-like proteins (known as UBLs) to their targets through
multienzyme cascades is a central mechanism to modulate protein functions. This process is …

All intracellular proteins and many extracellular proteins are continually “turning over;” ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

By affinity chromatography of a crude reticulocyte extract on ubiquitin-Sepharose, three
enzymes required for the conjugation of ubiquitin with proteins have been isolated. One is …

Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …