Deconvoluting the ontogeny of hematopoietic stem cells

IM Samokhvalov - Cellular and molecular life sciences, 2014 - Springer
Two different models describe the development of definitive hematopoiesis and
hematopoietic stem cells (HSCs). In one of these, the visceral yolk sac serves as a starting …

New insights into the regulation by RUNX1 and GFI1 (s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells

R Thambyrajah, R Patel, M Mazan, M Lie-a-Ling… - Cell cycle, 2016 - Taylor & Francis
The first hematopoietic cells are generated very early in ontogeny to support the growth of
the embryo and to provide the foundation to the adult hematopoietic system. There is a …

Cathelicidin LL-37 Promotes or inhibits cancer cell stemness depending on the tumor origin

GTC Neto, TM de Lima, HV Barbeiro, R Chammas… - Oncomedicine, 2016 - oncm.org
Antimicrobial peptides play critical protective roles in a range of human diseases, including
cancer. Multiple studies have demonstrated functions—such as proliferation, angiogenesis …

Return to the hematopoietic stem cell origin

IM Samokhvalov - Cell Regeneration, 2012 - Springer
Studying embryonic hematopoiesis is complicated by diversity of its locations in the
constantly changing anatomy and by the mobility of blood cell precursors. Embryonic …