CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

The role of protein phosphorylation in the life cycle of malaria parasites is slowly emerging.
Here we combine global phospho-proteomic analysis with kinome-wide reverse genetics to …

Although eukaryotic protein kinases (ePKs) contribute to many cellular processes, only three
Plasmodium falciparum ePKs have thus far been identified as essential for parasite asexual …

Background The post-genomic era of malaria research provided unprecedented insights
into the biology of Plasmodium parasites. Due to the large evolutionary distance to model …

Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …

Background Novel antimalarials should be effective across all species of malaria parasites
that infect humans, especially the two species that bear the most impact, Plasmodium …

Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites.
Many apicomplexan protein kinases are substantially different from their mammalian …

Malaria still remains one of the deadliest infectious diseases, and has a tremendous
morbidity and mortality impact in the developing world. The propensity of the parasites to …

The number of available and effective antimalarial drugs is quickly dwindling. This is mainly
because a number of drug resistance-associated mutations in malaria parasite genes, such …