Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non- malignant diseases. This is consistent with numerous findings about differentiation …
Somatic mutations in cancer genes have been detected in clonal expansions across healthy human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …
For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …
Understanding factors that shape the immune landscape across hematological malignancies is essential for immunotherapy development. We integrated over 8,000 …
F Wang, K Morita, CD DiNardo, K Furudate… - Nature …, 2021 - nature.com
Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in approximately 40% of acute …
ER Adelman, HT Huang, A Roisman, A Olsson… - Cancer discovery, 2019 - AACR
Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of …
T Lee Chong, EL Ahearn, L Cimmino - Frontiers in cell and …, 2019 - frontiersin.org
The erasure of epigenetic modifications across the genome of somatic cells is an essential requirement during their reprogramming into induced pluripotent stem cells (iPSCs). Vitamin …
Acute myeloid leukemia (AML) is characterised by a series of genetic and epigenetic alterations that result in deregulation of transcriptional networks. One understudied source of …
G Montalban-Bravo, CD DiNardo - Future Oncology, 2018 - Taylor & Francis
Isocitrate dehydrogenases (IDHs) are enzymes involved in multiple metabolic and epigenetic cellular processes. Mutations in IDH1 or IDH2 are detected in approximately 20 …