The roles of DNA, RNA and histone methylation in ageing and cancer

EM Michalak, ML Burr, AJ Bannister… - Nature reviews Molecular …, 2019 - nature.com
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

DNA hypermethylation in disease: mechanisms and clinical relevance

M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

AS Nam, N Dusaj, F Izzo, R Murali, RM Myers… - Nature …, 2022 - nature.com
Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …

The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML

D Vetrie, GV Helgason, M Copland - Nature Reviews Cancer, 2020 - nature.com
For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …

[HTML][HTML] Immunogenomic landscape of hematological malignancies

O Dufva, P Pölönen, O Brück, MAI Keränen, J Klievink… - Cancer Cell, 2020 - cell.com
Understanding factors that shape the immune landscape across hematological
malignancies is essential for immunotherapy development. We integrated over 8,000 …

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

F Wang, K Morita, CD DiNardo, K Furudate… - Nature …, 2021 - nature.com
Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant
leukemic blasts and provide durable clinical responses in approximately 40% of acute …

Aging human hematopoietic stem cells manifest profound epigenetic reprogramming of enhancers that may predispose to leukemia

ER Adelman, HT Huang, A Roisman, A Olsson… - Cancer discovery, 2019 - AACR
Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an
increased risk of myeloid malignancies. We performed an integrative characterization of …

Reprogramming the epigenome with vitamin C

T Lee Chong, EL Ahearn, L Cimmino - Frontiers in cell and …, 2019 - frontiersin.org
The erasure of epigenetic modifications across the genome of somatic cells is an essential
requirement during their reprogramming into induced pluripotent stem cells (iPSCs). Vitamin …

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

Ö Deniz, M Ahmed, CD Todd, A Rio-Machin… - Nature …, 2020 - nature.com
Acute myeloid leukemia (AML) is characterised by a series of genetic and epigenetic
alterations that result in deregulation of transcriptional networks. One understudied source of …

The role of IDH mutations in acute myeloid leukemia

G Montalban-Bravo, CD DiNardo - Future Oncology, 2018 - Taylor & Francis
Isocitrate dehydrogenases (IDHs) are enzymes involved in multiple metabolic and
epigenetic cellular processes. Mutations in IDH1 or IDH2 are detected in approximately 20 …