[HTML][HTML] Factors influencing the blood-brain barrier permeability

Y Zhao, L Gan, L Ren, Y Lin, C Ma, X Lin - Brain research, 2022 - Elsevier
The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …

The blood–brain barrier endothelium: a target for pro-inflammatory cytokines

KD Rochfort, PM Cummins - Biochemical Society Transactions, 2015 - portlandpress.com
An intact functioning blood–brain barrier (BBB) is fundamental to proper homoeostatic
maintenance and perfusion of the central nervous system (CNS). Inflammatory damage to …

TNF-α and IL-1β modulate blood-brain barrier permeability and decrease amyloid-β peptide efflux in a human blood-brain barrier model

R Versele, E Sevin, F Gosselet, L Fenart… - International journal of …, 2022 - mdpi.com
The blood-brain barrier (BBB) is a selective barrier and a functional gatekeeper for the
central nervous system (CNS), essential for maintaining brain homeostasis. The BBB is …

Brain endothelial cell junctions after cerebral hemorrhage: changes, mechanisms and therapeutic targets

RF Keep, AV Andjelkovic, J Xiang… - Journal of Cerebral …, 2018 - journals.sagepub.com
Vascular disruption is the underlying cause of cerebral hemorrhage, including intracerebral,
subarachnoid and intraventricular hemorrhage. The disease etiology also involves cerebral …

Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury

CL Eastman, R D'Ambrosio, T Ganesh - Neuropharmacology, 2020 - Elsevier
Traumatic brain injury (TBI) is a leading cause of death and disability in young adults
worldwide. TBI survival is associated with persistent neuropsychiatric and neurological …

Occludin regulation of blood–brain barrier and potential therapeutic target in ischemic stroke

S Yuan, KJ Liu, Z Qi - Brain circulation, 2020 - journals.lww.com
Occludin is a key structural component of the blood–brain barrier (BBB) that has recently
become an important focus of research in BBB damages. Many studies have demonstrated …

Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches

S Shekhar, MW Cunningham, MR Pabbidi… - European journal of …, 2018 - Elsevier
Ischemic stroke is a devastating and debilitating medical condition with limited therapeutic
options. However, accumulating evidence indicates a central role of inflammation in all …

Infection of endothelial cells by dengue virus induces ROS production by different sources affecting virus replication, cellular activation, death and vascular …

LM Meuren, EB Prestes, MP Papa… - Frontiers in …, 2022 - frontiersin.org
Exacerbated inflammatory response and altered vascular function are hallmarks of dengue
disease. Reactive oxygen species (ROS) production has been associated to endothelial …

Endothelial progenitor cells: Potential novel therapeutics for ischaemic stroke

U Bayraktutan - Pharmacological Research, 2019 - Elsevier
Stroke is classified into two main groups depending on its aetiology; ischaemic stroke and
haemorrhagic stroke which successively develop from the occlusion or rupture of an artery …

LPS induces occludin dysregulation in cerebral microvascular endothelial cells via MAPK signaling and augmenting MMP‐2 Levels

L Qin, W Huang, X Mo, Y Chen… - Oxidative medicine and …, 2015 - Wiley Online Library
Disrupted blood‐brain barrier (BBB) integrity contributes to cerebral edema during central
nervous system infection. The current study explored the mechanism of lipopolysaccharide …