The glymphatic system: a novel component of fundamental neurobiology

LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics

ST Proulx - Cellular and Molecular Life Sciences, 2021 - Springer
Cerebrospinal fluid (CSF) is produced by the choroid plexuses within the ventricles of the
brain and circulates through the subarachnoid space of the skull and spinal column to …

Development and evaluation of an artificial intelligence system for COVID-19 diagnosis

C Jin, W Chen, Y Cao, Z Xu, Z Tan, X Zhang… - Nature …, 2020 - nature.com
Early detection of COVID-19 based on chest CT enables timely treatment of patients and
helps control the spread of the disease. We proposed an artificial intelligence (AI) system for …

Entry and exit of extracellular vesicles to and from the blood circulation

D Iannotta, AW Kijas, AE Rowan, J Wolfram - Nature Nanotechnology, 2024 - nature.com
Extracellular vesicles (EVs) are biological nanoparticles that promote intercellular
communication by delivering bioactive cargo over short and long distances. Short-distance …

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

MJ Ansari, RR Rajendran, S Mohanto, U Agarwal… - Gels, 2022 - mdpi.com
A prominent research topic in contemporary advanced functional materials science is the
production of smart materials based on polymers that may independently adjust their …

Applications of surface modification technologies in nanomedicine for deep tumor penetration

Z Li, X Shan, Z Chen, N Gao, W Zeng… - Advanced …, 2021 - Wiley Online Library
The impermeable barrier of solid tumors due to the complexity of their components limits the
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

H Li, Q Luo, H Zhang, X Ma, Z Gu, Q Gong… - Chemical Society …, 2023 - pubs.rsc.org
Cancer radio-immunotherapy, integrating external/internal radiation therapy with immuno-
oncology treatments, emerges in the current management of cancer. A growing number of …

Chemical strategies to boost cancer vaccines

WH Li, YM Li - Chemical reviews, 2020 - ACS Publications
Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

[HTML][HTML] An update on oral drug delivery via intestinal lymphatic transport

Z Zhang, Y Lu, J Qi, W Wu - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Orally administered drug entities have to survive the harsh gastrointestinal environment,
penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the …

Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage

J Chen, L Wang, H Xu, L Xing, Z Zhuang… - Nature …, 2020 - nature.com
Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the
pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been …