The tumor suppressor protein p53 induces or represses the expression of a variety of target
genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or …

Even 30 years after its discovery, the tumor suppressor protein p53 is still somewhat of an
enigma. p53's intimate and multifaceted role in the cell cycle is mirrored in its equally …

Upon DNA damage and other types of stress, p53 induces either cell-cycle arrest or
apoptosis depending on the cellular context. However, the molecular mechanisms that …

The mechanisms by which eukaryotic cells sense DNA double-strand breaks (DSBs) in
order to initiate checkpoint responses are poorly understood. 53BP1 is a conserved …

The tumor suppressor protein p53 is inactivated by mutation in about half of all human
cancers. Most mutations are located in the DNA-binding domain of the protein. It is …

p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the
high degree of structural similarity shared by the p53 family members, p73 and p63 can bind …

A common ancestor to the three p53 family members of human genes p53, p63, and p73 is
first detected in the evolution of modern‐day sea anemones, in which both structurally and …

The DNA-binding domain of the tumor suppressor p53 is inactivated by mutation in≈ 50% of
human cancers. We have solved high-resolution crystal structures of several oncogenic …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

Germline apoptosis shares with somatic apoptosis a reliance on key components of the core
apoptotic machinery, including CED-3 and CED-4. However, germline apoptosis differs from …