Conservation, acquisition, and functional impact of sex-biased gene expression in mammals

S Naqvi, AK Godfrey, JF Hughes, ML Goodheart… - Science, 2019 - science.org
INTRODUCTION Sex differences are widespread in humans and other mammals. For
example, the distribution of height or body size is shifted upwards in males relative to …

A robust method uncovers significant context-specific heritability in diverse complex traits

A Dahl, K Nguyen, N Cai, MJ Gandal, J Flint… - The American Journal of …, 2020 - cell.com
Gene-environment interactions (GxE) can be fundamental in applications ranging from
functional genomics to precision medicine and is a conjectured source of substantial …

Heritability jointly explained by host genotype and microbiome: will improve traits prediction?

D Awany, ER Chimusa - Briefings in Bioinformatics, 2021 - academic.oup.com
As we observe the th anniversary of the publication by Robertson that formalized the notion
of 'heritability', geneticists remain puzzled by the problem of missing/hidden heritability …

GxEMM: Extending linear mixed models to general gene-environment interactions

A Dahl, N Cai, J Flint, N Zaitlen - BioRxiv, 2018 - biorxiv.org
Gene-environment interaction (GxE) is a well-known source of non-additive inheritance. GxE
can be important in applications ranging from basic functional genomics to precision …