Hypoxia is one of the strongest environmental drivers of cellular and physiological
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …

MicroRNAs are small non-coding RNA (18–24 nt long) that fine-tune gene expression at the
post-transcriptional level. With the advent of “multi-omics” analysis and sequencing …

The naked mole-rat of the family Bathyergidae has been the showpiece for ageing research
as they contradict the traditional understanding of the oxidative stress theory of ageing …

The doubly labeled water (DLW) technique and indirect calorimetry enable measurement of
an animal's daily energy expenditure (DEE, kJ/day), resting metabolic rate (RMR, kJ/d) …

Hypoxia poses a major physiological challenge for mammals and has significant impacts on
cellular and systemic metabolism. As with many other small rodents, naked mole-rats …

Naked mole–rats are among the mammalian champions of hypoxia tolerance. They evolved
adaptations centered around reducing metabolic rate to overcome the challenges …

The effect of the macro-and microclimate on small mammal thermoregulation in the past has
been studied independently instead of investigating the dual effect of both the components …

Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide
(CO) and iron into circulation. These byproducts of heme degradation can have potent …

Mammals have evolved circadian rhythms in internal biological processes and behaviors,
such as locomotor activity (LA), to synchronize to the environmental conditions they …

Naked mole-rats are among the few mammals with the ability to endure severe hypoxia.
These unique rodents use metabolic rate depression along with various molecular …