The highly heterogeneous nature of neuronal cell types and their connections presents a
major challenge to the characterization of neural circuits at the protein level. New …

At its most fundamental level, life is a collection of synchronized cellular processes driven by
interactions among biomolecules. Proximity labeling has emerged as a powerful technique …

Understanding how protein–protein interaction networks in the brain give rise to cognitive
functions necessitates their characterization in live animals. However, tools available for this …

The plasma membrane proteome is a rich resource of functionally important and
therapeutically relevant protein targets. Distinguished by high hydrophobicity, heavy …

Axon initial segment (AIS) cell surface proteins mediate key biological processes in neurons
including action potential initiation and axo-axonic synapse formation. However, few AIS cell …

Membrane proteins, particularly those on the cell surface, play pivotal roles in diverse
physiological processes, and their dysfunction is linked to a broad spectrum of diseases …

The central nervous system (CNS) comprises diverse and morphologically complex cells. To
understand the molecular basis of their physiology, it is crucial to assess proteins expressed …

In the last two decades, our knowledge of synaptic proteomes and their relationship to
normal brain function and neuropsychiatric disorders has been expanding rapidly through …

Proximity-dependent biotinylation coupled with mass spectrometry enables the
characterization of subcellular proteomes. This technique has significantly advanced …

Protein trafficking is a fundamental process with profound implications for both intracellular
and intercellular functions. Proximity labeling (PL) technology has emerged as a powerful …