Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …

The mammalian circadian clock is built on a feedback loop in which PER and CRY proteins
repress their own transcription. We found that in mouse liver nuclei all three PERs, both …

The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by
regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These …

Living organisms depend on timely and organized interactions between proteins linked in
interactomes of high complexity. The recent increased precision by which protein …

The immune system is under control of the circadian clock. Many of the circadian rhythms
observed in the immune system originate in direct interactions between components of the …

Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon
serial transplantation in animal models, and elimination of this cell population is required for …

Mammalian basic HLH (helix–loop–helix)–PER–ARNT–SIM (bHLH–PAS) proteins are
heterodimeric transcription factors that sense and respond to environmental signals (such as …

From cyanobacteria to mammals, organisms have evolved timing mechanisms to adapt to
environmental changes in order to optimize survival and improve fitness. To anticipate these …

Metabolic demands fluctuate rhythmically and rely on coordination between the circadian
clock and nutrient-sensing signalling pathways, yet mechanisms of their interaction remain …