Context and Objective: In most populations a greater proportion of men have hepatic
steatosis than women. Sex-specific differences in hepatic dietary fatty acid (FA) metabolism …

Abstract Sphingosine-1-phosphate (S1P) has gained special attention in the high-density
lipoprotein (HDL) field because HDL is the most prominent plasma carrier of S1P and …

Skin interstitial fluid (ISF) is an emerging source of biomarkers for disease diagnosis and
prognosis. Microneedle (MN) patch has been identified as an ideal platform to extract ISF …

Atherosclerosis is a chronic inflammatory disease promoted by hyperlipidemia. Several
studies support FOXP3-positive regulatory T cells (Tregs) as inhibitors of atherosclerosis; …

Atherosclerosis is one of the most common vascular disorders. Endothelial cell (EC)
dysfunction and vascular smooth muscle cell (VSMC) proliferation contributes to the …

Background Intervention strategies for obesity are global issues that require immediate
attention. One approach is to exploit the growing consensus that beneficial gut microbiota …

Compared with humans, rodents have higher synthesis of cholesterol and bile acids (BAs)
and faster clearance and lower levels of serum LDL-cholesterol. Paradoxically, they …

Background—Atherosclerosis is a multifactorial disease in which inflammatory processes
play an important role. Inflammation underlies lesion evolution at all stages, from …

Objective—To gain insight into the function of proprotein convertase subtilisin kexin type 9
(PCSK9) in humans by establishing whether circulating levels are influenced by diurnal …

Liver macrophages (LMs) have been proposed to contribute to metabolic disease through
secretion of inflammatory cytokines. However, anti-inflammatory drugs lead to only modest …