Compensatory mutations, due to their ability to mask the deleterious effects of another
mutation, are important for the adaptation and evolution of most organisms. Resistance to …

At present, the successful transmission of drug‐resistant Mycobacterium tuberculosis,
including multidrug‐resistant (MDR) and extensively drug‐resistant (XDR) strains, in human …

The rapid diagnosis of rifampin resistance is hampered by a reported insufficient specificity
of molecular techniques for detection of rpoB mutations. Our objective for this study was to …

Catalyzed hairpin assembly (CHA) is a robust enzyme-free signal-amplification reaction that
has a wide range of potential applications, especially in biosensing. Although most studies …

Creating and characterizing individual genetic variants remains limited in scale, compared
to the tremendous variation both existing in nature and envisioned by genome engineers …

This study examines the intrinsic fitness burden associated with RNA polymerase (rpoB)
mutations conferring rifampin resistance in Escherichia coli K12 (MG1655) and explores the …

The prevalence of recently described mutation V176F, located in the beginning of the rpoB
gene and associated with rifampin resistance and the wild-type cluster I sequence, was …

Correct and rapid diagnosis is essential in the management of multidrug-resistant
tuberculosis (MDR-TB). In this population-based study of 61 patients with drug-resistant …

Mutations in an 81-bp region of the rpoB gene associated with rifampin resistance were
studied in 41 rifampin-resistant clinical strains of Mycobacterium tuberculosis isolated in …

Mutations in the 81-bp rifampin resistance-determining region (RRDR) of the rpoB gene
were analyzed by DNA sequencing of 50 Mycobacterium tuberculosis clinical isolates (44 …