Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

Germ-line and somatic mutations in genes that promote homology-directed repair (HDR),
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …

Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies,
most notably tumors of the breast and ovaries. The proteins encoded by these genes have …

Mutations in the tumor suppressor BRCA2 predominantly predispose to breast cancer.
Paradoxically, while loss of BRCA2 promotes tumor formation, it also causes cell lethality …

CEP55 was initially identified as a pivotal component of abscission, the final stage of
cytokinesis, serving to regulate the physical separation of two daughter cells. Over the past …

Abscission, the final step of cytokinesis, mediates the severing of the membrane tether, or
midbody, that connects two daughter cells. It is now recognized that abscission is a complex …

The DNA damage response recognizes DNA lesions and coordinates a cell cycle arrest with
the repair of the damaged DNA, or removal of the affected cells to prevent the passage of …

Missense variants in the BRCA 2 gene are routinely detected during clinical screening for
pathogenic mutations in patients with a family history of breast and ovarian cancer. These …

Many variants of uncertain significance (VUS) have been identified in BRCA2 through
clinical genetic testing. VUS pose a significant clinical challenge because the contribution of …

The centrosomal protein, CEP 55, is a key regulator of cytokinesis, and its overexpression is
linked to genomic instability, a hallmark of cancer. However, the mechanism by which it …