Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
H Maecker, V Jonnalagadda, S Bhakta… - MAbs, 2023 - Taylor & Francis
The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial recent developmental investment and subsequent drug approvals over the past 6 years. In …
W Zhang, R Taheri-Ledari, F Ganjali, FH Afruzi… - Heliyon, 2022 - cell.com
Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or decorated with biologically active targeting ligands. These targeting ligands can be …
Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are limited data on the heterogeneity of PSMA tissue expression in metastatic …
Simple Summary This review summarizes the current knowledge on mesothelin's function, its role in cancer, and opportunities for immunotherapeutic targeting of mesothelin …
C Ceci, PM Lacal, G Graziani - Pharmacology & Therapeutics, 2022 - Elsevier
Antibody–drug conjugates (ADCs) constitute a relatively new group of anticancer agents, whose first appearance took place about two decades ago, but a renewed interest occurred …
M Entezam, MJ Sanaei, Y Mirzaei, AH Mer… - Life sciences, 2023 - Elsevier
Gastric cancer (GC) is a severe malignancy, accounting for the third most common cancer death worldwide. Despite the development of chemo-radiation therapy, there has not been …
C Liu, R Miao, F Raza, H Qian, X Tian - European Journal of Medicinal …, 2023 - Elsevier
Diabetic neuropathic pain (DNP) is a common, complex, and severe complication of diabetes. It can lead to increased mortality, lower-limb amputations, and distressing …