Clinical and translational advances in ovarian cancer therapy

PA Konstantinopoulos, UA Matulonis - Nature Cancer, 2023 - nature.com
Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and
is initially very responsive to platinum-based chemotherapy. However, the majority of …

Exploring the next generation of antibody–drug conjugates

K Tsuchikama, Y Anami, SYY Ha… - Nature Reviews Clinical …, 2024 - nature.com
Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …

The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress

JM Sasso, R Tenchov, R Bird, KA Iyer… - Bioconjugate …, 2023 - ACS Publications
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …

Exploration of the antibody–drug conjugate clinical landscape

H Maecker, V Jonnalagadda, S Bhakta… - MAbs, 2023 - Taylor & Francis
The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial
recent developmental investment and subsequent drug approvals over the past 6 years. In …

Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy

W Zhang, R Taheri-Ledari, F Ganjali, FH Afruzi… - Heliyon, 2022 - cell.com
Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or
decorated with biologically active targeting ligands. These targeting ligands can be …

[HTML][HTML] Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer

E Sayar, RA Patel, IM Coleman, MP Roudier, A Zhang… - JCI insight, 2023 - ncbi.nlm.nih.gov
Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate
cancer. There are limited data on the heterogeneity of PSMA tissue expression in metastatic …

Mesothelin: an immunotherapeutic target beyond solid tumors

JR Faust, D Hamill, EA Kolb, A Gopalakrishnapillai… - Cancers, 2022 - mdpi.com
Simple Summary This review summarizes the current knowledge on mesothelin's function,
its role in cancer, and opportunities for immunotherapeutic targeting of mesothelin …

Antibody-drug conjugates: Resurgent anticancer agents with multi-targeted therapeutic potential

C Ceci, PM Lacal, G Graziani - Pharmacology & Therapeutics, 2022 - Elsevier
Antibody–drug conjugates (ADCs) constitute a relatively new group of anticancer agents,
whose first appearance took place about two decades ago, but a renewed interest occurred …

Current progress and challenges of immunotherapy in gastric cancer: A focus on CAR-T cells therapeutic approach

M Entezam, MJ Sanaei, Y Mirzaei, AH Mer… - Life sciences, 2023 - Elsevier
Gastric cancer (GC) is a severe malignancy, accounting for the third most common cancer
death worldwide. Despite the development of chemo-radiation therapy, there has not been …

Research progress and challenges of TRPV1 channel modulators as a prospective therapy for diabetic neuropathic pain

C Liu, R Miao, F Raza, H Qian, X Tian - European Journal of Medicinal …, 2023 - Elsevier
Diabetic neuropathic pain (DNP) is a common, complex, and severe complication of
diabetes. It can lead to increased mortality, lower-limb amputations, and distressing …