Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

Glucokinase is a key regulatory enzyme in the pancreatic beta‐cell. It plays a crucial role in
the regulation of insulin secretion and has been termed the glucose sensor in pancreatic …

Context: Hypoglycemia due to congenital hyperinsulinism (HI) is caused by mutations in 9
genes. Objective: Our objective was to correlate genotype with phenotype in 417 children …

ATP-sensitive potassium (KATP) channels, so named because they are inhibited by
intracellular ATP, play key physiological roles in many tissues. In pancreatic β cells, these …

Genome-wide association studies have identified a number of signals for both Type 2
Diabetes and related quantitative traits. For the majority of loci, the transition from …

The glucokinase (GCK) gene was one of the first candidate genes to be identified as a
human “diabetes gene". Subsequently, important advances were made in understanding the …

Glucokinase, a unique isoform of the hexokinase enzymes, which are known to
phosphorylate d-glucose and other hexoses, was identified during the past three to four …

Background Glucokinase (GCK) regulates insulin secretion to maintain appropriate blood
glucose levels. Sequence variants can alter GCK activity to cause hyperinsulinemic …

Abstract Type 2 diabetes (T2D) is a global health problem characterised by chronic
hyperglycaemia due to inadequate insulin secretion. Because glucose must be metabolised …

The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and molecular
genetic features that are ideal for its primary role as glucose sensor in a network of …