Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

Owing to recent advances in mass spectrometry (MS), tens to hundreds of proteins, lipids,
and small molecules can be measured in single cells. The ability to characterize the …

Abstract The Human Reference Atlas (HRA) aims to map all of the cells of the human body
to advance biomedical research and clinical practice. This Perspective presents …

Mass spectrometry imaging (MSI) is a powerful tool for label-free mapping of the spatial
distribution of proteins in biological tissues. We have previously demonstrated imaging of …

Increasing evidence suggests that the spatial distribution of biomolecules within cells is a
critical component in deciphering single-cell molecular heterogeneity. State-of-the-art single …

Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited
proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS) …

Previously, we have demonstrated native mass spectrometry imaging (native MSI) in which
the spatial distribution of proteins maintained in their native-like, folded conformations was …

Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of
hundreds of molecules in biological samples with high sensitivity and molecular specificity …