Perivascular niches in the kidney comprise heterogeneous cell populations, including
pericytes and fibroblasts, with distinct functions. These perivascular cells have crucial roles …

Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and a potential therapeutic
target. However, there are conceptual and practical challenges to directly targeting kidney …

Chronic kidney disease (CKD) affects approximately 10% of the worldwide population;
anaemia is a frequent complication. Inadequate erythropoietin production and absolute or …

Hypoxia and oxidative stress are the common causes of various types of kidney injury.
During recent years, the studies on hypoxia inducible factor‐(HIF‐) 1 attract more and more …

Rationale & Objective Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are
novel, orally administered agents for anemia management in chronic kidney disease (CKD) …

Ozone (O3) is a criteria air pollutant with the most frequent incidence of exceeding air quality
standards. Inhalation of O3 is known to cause lung inflammation and consequent systemic …

Studies have highlighted the significant involvement of kidney pericytes in renal fibrosis.
Kidney pericytes, classified as interstitial mesenchymal cells, are extensively branched …

Renal fibrosis is the final stage of most progressive kidney diseases. Chronic kidney disease
(CKD) is associated with high comorbidity and mortality. Thus, preventing fibrosis and …

Anemia is common in patients with chronic kidney disease (CKD) and is mainly caused by
insufficient production of erythropoietin from fibrotic kidney. Because anemia impairs quality …

Renal fibrosis, the result of different pathological processes, impairs kidney function and
architecture, and usually leads to renal failure development. Piezo1 is a mechanosensitive …