Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
What are 3′ UTRs doing?
C Mayr - Cold Spring Harbor perspectives in biology, 2019 - cshperspectives.cshlp.org
SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
Cancer therapies that target epigenetic repressors can mediate their effects by activating
retroelements within the human genome. Retroelement transcripts can form double …
retroelements within the human genome. Retroelement transcripts can form double …
An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability
Genome-wide association studies have identified thousands of noncoding variants
associated with human traits and diseases. However, the functional interpretation of these …
associated with human traits and diseases. However, the functional interpretation of these …
N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
M Bartosovic, HC Molares, P Gregorova… - Nucleic acids …, 2017 - academic.oup.com
Abstract N6-methyladenosine (m6A) is the most abundant base modification found in
messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase …
messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase …
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3′ end sequencing
CJ Herrmann, R Schmidt, A Kanitz, P Artimo… - Nucleic acids …, 2020 - academic.oup.com
Generated by 3′ end cleavage and polyadenylation at alternative polyadenylation (poly
(A)) sites, alternative terminal exons account for much of the variation between human …
(A)) sites, alternative terminal exons account for much of the variation between human …
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia
DNA mutations are known cancer drivers. Here we investigated whether mRNA events that
are upregulated in cancer can functionally mimic the outcome of genetic alterations. RNA …
are upregulated in cancer can functionally mimic the outcome of genetic alterations. RNA …
[HTML][HTML] A deep neural network for predicting and engineering alternative polyadenylation
Alternative polyadenylation (APA) is a major driver of transcriptome diversity in human cells.
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …
Function of HNRNPC in breast cancer cells by controlling the dsRNA‐induced interferon response
Elevated expression of RNA binding protein HNRNPC has been reported in cancer cells,
while the essentialness and functions of HNRNPC in tumors were not clear. We showed that …
while the essentialness and functions of HNRNPC in tumors were not clear. We showed that …
[HTML][HTML] Context-specific regulation and function of mRNA alternative polyadenylation
S Mitschka, C Mayr - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …