Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …

BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNAs regulating
gene expression that play roles in the pathogenesis of human diseases, including …

Aim: To investigate the status of Phosphatidylinositol 3‐kinase (PI3K)/PTEN/AKT/
mammalian target of rapamycin (mTOR) pathway and its correlation with clinicopathological …

Metastasis accounts for the vast majority of morbidity and mortality associated with
melanoma. Evidence suggests melanoma has a predilection for metastasis to particular …

Loss of tumor suppressor genes on chromosome 10 plays an important role in the
development of 30–60% of melanomas; however, the identity of these genes and the …

From the first reported role of the transcription factor RUNX2 in osteoblast and chondrocyte
differentiation and migration to its involvement in promigratory/proinvasive behavior of …

Identification of specific genes or signaling pathways involved in development of melanoma
could lead to new therapies that target and correct these defects. Recent studies have …

Background Colorectal carcinoma (CRC) is one of the leading causes of cancer-related
mortality worldwide. MicroRNAs (miRNAs, miRs) play important roles in carcinogenesis. MiR …

Background Our previous studies show that microRNA-92a (miR-92a) is overexpressed in
colorectal cancer (CRC) and is thought to be correlated with the development of the cancer …