Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

S Tartey, O Takeuchi - International reviews of immunology, 2017 - Taylor & Francis
The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which
include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin …

Influence of Toll‐like receptor gene polymorphisms to tuberculosis susceptibility in humans

S Thada, VL Valluri, SL Gaddam - Scandinavian journal of …, 2013 - Wiley Online Library
Tuberculosis (TB) is caused by M ycobacterium tuberculosis (M. tb), and it remains one of
the major bacterial infections worldwide. Innate immunity is an important arm of …

TLR9 and COVID-19: a multidisciplinary theory of a multifaceted therapeutic target

GFG Bezemer, J Garssen - Frontiers in Pharmacology, 2021 - frontiersin.org
By mapping the clinical pathophysiology of the novel coronavirus disease 2019 (COVID-19)
against insights from virology, immunology, genomics, epidemiology and pharmacology, it is …

Oral Immunization against PEDV with Recombinant Lactobacillus casei Expressing Dendritic Cell-Targeting Peptide Fusing COE Protein of PEDV in Piglets

X Hou, X Jiang, Y Jiang, L Tang, Y Xu, X Qiao, M Liu… - Viruses, 2018 - mdpi.com
Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets. In our
previous study, a genetically engineered Lactobacillus casei oral vaccine (pPG-COE …

Toll-like receptors and human disease: lessons from single nucleotide polymorphisms

YT Lin, A Verma, CP Hodgkinson - Current genomics, 2012 - ingentaconnect.com
Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-
associated molecular patterns, are critical for the normal function of the innate immune …

Impact of toll-like receptor 2 and 9 gene polymorphisms on COVID-19: susceptibility, severity, and thrombosis

AM Alhabibi, AS Hassan, NM Abd Elbaky… - Journal of …, 2023 - Taylor & Francis
Background Toll-like receptors (TLRs) play an important role in activation of innate and
adaptive immune responses. Aim We aimed to detect the association between TLR2 …

The role of TLR9 polymorphism in susceptibility to pulmonary tuberculosis

D Bharti, A Kumar, RS Mahla, S Kumar, H Ingle… - Immunogenetics, 2014 - Springer
Mycobacterium tuberculosis (MTB) is the causative agent of pulmonary tuberculosis (PTB), a
major health problem that leads to 1.5 million deaths annually. Host genetic factors play a …

[HTML][HTML] Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant …

M Fernández-Ruiz, I Corrales, M Arias… - American Journal of …, 2015 - Elsevier
In this study, we assessed the association between single-nucleotide polymorphisms
(SNPs) in seven candidate genes involved in orchestrating the immune response against …

Influence of single-nucleotide polymorphisms in TLR3 (rs3775291) and TLR9 (rs352139) on the risk of CMV infection in kidney transplant recipients

N Redondo, I Rodríguez-Goncer, P Parra… - Frontiers in …, 2022 - frontiersin.org
Risk stratification for cytomegalovirus (CMV) infection after kidney transplantation (KT)
remains to be determined. Since endosomal toll-like receptors (TLRs) are involved in viral …

Genetics of toll like receptor 9 in ANCA associated vasculitides

CA Husmann, JU Holle, F Moosig, S Mueller… - Annals of the …, 2014 - ard.bmj.com
Objectives To investigate the contribution of genetic polymorphisms of toll like receptor
(TLR) 9 and related genes on the susceptibility and clinical manifestation of anti-neutrophil …