Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

As a chronic metabolic disease, diabetes mellitus (DM) is broadly characterized by elevated
levels of blood glucose. Novel epidemiological studies demonstrate that some diabetic …

After decades of research and clinical trials there is still no cure for Alzheimer's disease
(AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the …

Emergence of the field of exosome biology has opened an exciting door to better
understand communication between cells. These tiny nanovesicles act as potent regulators …

Insulin‐degrading enzyme (IDE) function goes far beyond its known proteolytic role as a
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …

Alzheimer's disease (AD) is the most common neurodegenerative disease. The
accumulation of amyloid beta (Aβ) is the main pathology of AD. Metformin, a well‐known …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

Diabetic mellitus (DM) is the most communal metabolic disease resulting from a defect in
insulin secretion, causing hyperglycemia by promoting the progressive destruction of …

Impairment of biliverdin reductase-A (BVR-A) is an early event leading to brain insulin
resistance in AD. Intranasal insulin (INI) administration is under evaluation as a strategy to …