Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

Accumulating evidence suggests that many classes of DNA repeats exhibit attributes that
distinguish them from other genetic variants, including the fact that they are more liable to …

The emergence of drug resistance limits the efficacy of targeted therapies in human tumors.
The prevalent view is that resistance is a fait accompli: when treatment is initiated, cancers …

Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal
endothelial dystrophy and the leading indication for corneal transplantation worldwide …

Nickel (Ni) is known to be a major carcinogenic heavy metal. Occupational and
environmental exposure to Ni has been implicated in human lung and nasal cancers …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Genomic instability underlies many cancers and generates genetic variation that drives
cancer initiation, progression, and therapy resistance. In contrast with classical assumptions …

Fuchs endothelial corneal dystrophy (FECD) is a common cause for heritable visual loss in
the elderly. Since the first description of an association between FECD and common …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …