Quinazolinone analogs as potential therapeutic agents

P C. Sharma, G Kaur, R Pahwa… - Current medicinal …, 2011 - benthamdirect.com
Quinazolinone scaffold has been considered as a magic moiety possessing myriad
spectrum of medicinal activities. Diversity of biological response profile has attracted …

Synthesis and pharmacological investigation of novel 4-(2-methylphenyl)-1-substituted-4H-[1, 2, 4] triazolo [4, 3-a] quinazolin-5-ones as new class of H1 …

V Alagarsamy, M Rupeshkumar, K Kavitha… - European Journal of …, 2008 - Elsevier
A series of novel 1-substituted-4-(2-methylphenyl)-4H-[1, 2, 4] triazolo [4, 3-a] quinazolin-5-
ones were synthesized by the cyclization of 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin …

Synthesis, characterization, antitubercular and antibacterial activity, and molecular docking of 2, 3-disubstituted quinazolinone derivatives

KK Rajasekhar, ND Nizamuddin, AS Surur… - … and Reports in …, 2016 - Taylor & Francis
Quinazolinone derivatives, which are known for their versatile biological activities, have
been reported to show significant antibacterial and antitubercular activities. Fourteen …

Non‐Steroidal Antiinflammatory Agents Synthesis of Novel 2‐Pyrazolyl‐4(3H)‐Quinazolinones

AM Farghaly, I Chaaban, MA Khalil… - Archiv der …, 1990 - Wiley Online Library
Four novel series of pyrazolyl‐4 (3H)‐quinazolinones have been prepared through the
reaction of 3‐aryl‐2‐hydrazino‐4 (3H)‐quinazolinones with antipyrylazo‐derivatives of ethyl …

Synthesis of 1-substituted-4-(pyridin-4-yl)[1, 2, 4] triazolo [4, 3-a] quinazolin-5 (4H)-ones as a new class of H1-antihistaminic agents

M Gobinath, N Subramanian, V Alagarsamy… - Tropical Journal of …, 2015 - ajol.info
Purpose: To synthesize a new series of 1-substituted-4-(pyridin-4-yl)[1, 2, 4] triazolo [4, 3-a]
quinazolin-5 (4H)-ones and evaluate them for H1-antihistaminic activity with negligible side …

Synthesis and antibacterial activities of quinazolin-4 (3h)-one, 2-methyl-4 (3h)-quinazolinone and 2–phenyl-4 (3h)-quinazolinone

PO Osarumwense, MO Edema, CO Usifoh - International Journal of …, 2021 - ijbpsa.com
Background: Quinazoline and quinazolinone scaffolds represent an important class of
biologically active nitrogen heterocyclic compounds. Many marketed drugs are based on …

4-(3-Methoxyphenyl)-1-substituted-4H-[1, 2, 4] triazolo [4, 3-a] quinazolin-5-ones: new class of H1-antihistaminic agents

V Alagarsamy, HK Sharma, P Parthiban… - Die Pharmazie-An …, 2009 - ingentaconnect.com
A series of 1-substituted-4-(3-methoxyphenyl)-4H-[1, 2, 4] triazolo [4, 3-a] quinazolin-5-ones
were synthesized by the cyclization of 2-hydrazino-3-(3-methoxyphenyl)-3H-quinazolin-4 …

Design and synthesis of novel 2-(3-substituted propyl)-3-(2-methyl phenyl) quinazolin-4-(3H)-ones as a new class of H1-antihistaminic agents

V Alagarsamy, P Parthiban - Journal of Enzyme Inhibition and …, 2013 - Taylor & Francis
A series of novel 2-(3-substituted propyl)-3-(2-methyl phenyl) quinazolin-4-(3 H)-ones were
synthesized by the reaction of 2-(3-bromopropyl thio)-3-(2-methyl phenyl) quinazolin-4-(3 H) …

Synthesis of N‐Heteryl‐β‐[(2‐alkoxyethyl) oxy]/β [[2‐(N, N‐dialkyamino) ethyl] oxy] acetamide as Possible H,-Ant ihistaminics 1

ARR Rao, VM Reddy - Journal of Pharmaceutical Sciences, 1994 - Elsevier
Abstract The synthesis of β‐[2‐(alkoxyethyl) oxy]‐and β‐[[2‐(N, N‐dialkylamino) ethyl] oxy]
acetamides containing an N‐heteryl moiety is reported. Three heteryl systems, 2 …

Synthesis and Antimicrobial Evaluation of Some Quinazolinone Derivatives

AA Bekhit - Bulletin of Pharmaceutical Sciences Assiut University, 1995 - journals.ekb.eg
SOME QUINAZOLINONE DERIVATIVES Page 1 Bull. Pharm. Sci., Assiut University, Vol. 18, Part
2, December 1995, pp. 107-714 SYNTHESIS AND ANTIMICROBIAL, EVALUATION OF SOME …