Amyloid-β1–42 (Aβ42) peptide aggregate formation in the brain plays a crucial role in the
onset and progression of Alzheimer's disease. According to published research, the Aβ …

Light chain (AL) amyloidosis is a progressive, degenerative disease characterized by the
misfolding and amyloid deposition of immunoglobulin light chain (LC). The amyloid deposits …

The structure of wild-type pentameric C-reactive protein (CRP) is stabilized by two calcium
ions that are required for the binding of CRP to its ligand phosphocholine. CRP in its …

C-reactive protein (CRP) binds to phosphocholine (PCh)-containing substances and
subsequently activates the complement system to eliminate the ligand. The PCh-binding …

Early events in immunoglobulin light chain (AL) amyloid formation are especially important
as some early intermediates formed during the aggregation reaction are cytotoxic and play a …

Immunoglobulin light chain (AL) amyloidosis involves the deposition of insoluble
monoclonal AL protein fibrils in the extracellular space of different organs leading to …

Background Light-chain (AL) amyloidosis frequently involves severe multiple end-organ
damage, thus affecting prognosis. As the current disease staging system is based only on …

To study the effect of mechanical shocks on the neurodegenerative-related fibril-formation
protein, the aggregation process, especially the initial oligomerization of a model yeast prion …

Amyloidoses are protein misfolding diseases in which monomeric protein misfolds into fibrils
and accumulates in different organs. In light chain (AL) amyloidosis, fibrils are formed from …

The work within this dissertation lies at the intersection of chemistry, biophysics, and
materials science to better understand how structural proteins effect known or new functions …