Gastric cancer remains one of the most common cancers worldwide and one of the leading
cause for cancer-related deaths. Gastric adenocarcinoma is a multifactorial disease that is …

Epigenetic mechanisms play a crucial role in regulating gene expression. The main
mechanisms involve methylation of DNA and covalent modifications of histones by …

The metabolite of vitamin D, 1α, 25-dihydroxyvitamin D3 (also known as calcitriol), is a
biologically active molecule required to maintain the physiological functions of several target …

In the last two decades vitamin D (VD) research has demonstrated new extraskeletal actions
of this pre-hormone, suggesting a protective role of this secosteroid in the onset, progression …

The Wnt/β-catenin signaling pathway is abnormally activated in most colorectal cancers and
in a proportion of other neoplasias. This activation initiates or contributes to carcinogenesis …

It is thought that germ cells and preimplantation embryos during development are most
susceptible to endogenous and exogenous environmental factors because the epigenome …

Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous
system characterised by incoordination, sensory loss, weakness, changes in bladder …

Atherosclerotic occlusive diseases and aneurysms that affect large and medium-sized
arteries outside the cardiac and cerebral circulation are collectively known as peripheral …

Background Vitamin D has anticarcinogenic and immune-related properties and may protect
against some diseases, including breast cancer. Vitamin D affects gene transcription and …

Cancer-associated mutations have been identified in the metabolic genes succinate
dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) …