[HTML][HTML] Transcriptomic and metabolomic insights into the role of the flgK gene in the pathogenicity of Pseudomonas plecoglossicida to orange-spotted grouper …

B Yuan, LM Zhao, ZX Zhuang, XR Wang, Q Fu… - Zoological …, 2022 - ncbi.nlm.nih.gov
Pseudomonas plecoglossicida is the pathogen responsible for visceral white spot disease in
large yellow croaker (Larimichthys crocea) and orange-spotted grouper (Epinephelus …

The TRPV6 Calcium Channel and Its Relationship with Cancer

Y Wang, X Deng, R Zhang, H Lyu, S Xiao, D Guo… - Biology, 2024 - mdpi.com
Simple Summary TRPV6 is a highly selective channel for calcium ions and plays an
important role in maintaining calcium homeostasis. Some evidence suggests that it is …

Improved electrophile design for exquisite covalent molecule selectivity

JL Montaño, BJ Wang, RF Volk… - ACS Chemical …, 2022 - ACS Publications
Covalent inhibitors are viable therapeutics. However, off-target reactivity challenges the
field. Chemists have attempted to solve this issue by varying the reactivity attributes of …

Cytotoxicity and Thermal Characterization Assessment of Excipients for the Development of Innovative Lyophilized Formulations for Oncological Applications

F Susa, T Limongi, M Millone, V Cauda, R Pisano - Processes, 2022 - mdpi.com
Freeze-drying, also known as lyophilization, significantly improves the storage, stability,
shelf life, and clinical translation of biopharmaceuticals. On the downside, this process faces …

B cell receptor signaling drives APOBEC3 expression via direct enhancer regulation in chronic lymphocytic leukemia B cells

Z Wang, H Yan, JC Boysen, CR Secreto… - Blood cancer …, 2022 - nature.com
Constitutively activated B cell receptor (BCR) signaling is a primary biological feature of
chronic lymphocytic leukemia (CLL). The biological events controlled by BCR signaling in …

T cell exhaustion: Supremacy in leukemia as for disease and therapy

NK Mohamed, MA El-Mokhtar… - Bulletin of …, 2024 - bpsa.journals.ekb.eg
In this review, an overview of exhausted T cells in acute and chronic leukemias including
myelocytic and lymphoblastic leukemia was made to browse this important subset of cells …

Die Rolle des Transkriptionsfaktors NFAT2 in der NK-Zell-vermittelten Immunüberwachung der chronisch lymphatischen Leukämie

SM Greiner - 2023 - ub01.uni-tuebingen.de
Märklin et al haben gezeigt, dass der genetische Verlust von NFAT2, bekannt als wichtiger
Transkriptionsfaktor in der Lymphozytenentwicklung, einen aggressiven Verlauf der CLL …