Synthesis and characterization of novel hydrazide–hydrazones and the study of their structure–antituberculosis activity

KK Bedia, O Elçin, U Seda, K Fatma, S Nathaly… - European journal of …, 2006 - Elsevier
A series of hydrazide–hydrazones, based on a series of 4-substituted benzoic acid, were
synthesized, and their structures were elucidated and screened for the antituberculosis …

[HTML][HTML] Alzheimer's disease treatment: The share of herbal medicines

M Soheili, M Karimian, G Hamidi… - Iranian journal of basic …, 2021 - ncbi.nlm.nih.gov
One of the most frequent forms of dementia in neurological disorders is Alzheimer's disease
(AD). It is a chronic neurodegenerative disease characterized by impaired learning and …

Synthesis and structure–antituberculosis activity relationship of 1H-indole-2, 3-dione derivatives

N Karalı, A Gürsoy, F Kandemirli, N Shvets… - Bioorganic & medicinal …, 2007 - Elsevier
New series of 5-fluoro-1H-indole-2, 3-dione-3-thiosemicarbazones 2a–k and 5-fluoro-1-
morpholino/piperidinomethyl-1H-indole-2, 3-dione-3-thiosemicarbazones 3a–r were …

Design, synthesis and evaluation of hesperetin derivatives as potential multifunctional anti-Alzheimer agents

B Li, AL Huang, YL Zhang, Z Li, HW Ding, C Huang… - Molecules, 2017 - mdpi.com
In this study we designed and synthesized a series of new hesperetin derivatives on the
basis of the structural characteristics of acetylcholinesterase (AChE) dual-site inhibitors. The …

QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease

KY Wong, PR Duchowicz… - Mini reviews in …, 2012 - ingentaconnect.com
This article reviews multi-criteria QSAR applications on Acetylcholinesterase inhibitors as
palliative drugs for Alzheimer's Disease, published in the period 2001-2011. It includes …

Molecular interaction of human acetylcholinesterase with trans-tephrostachin and derivatives for Alzheimer's disease

A Pitchai, RK Rajaretinam, R Mani, N Nagarajan - Heliyon, 2020 - cell.com
Abstract Alzheimer's disease (AD), a neurodegenerative disorder affects more than 35
million people globally. Acetylcholinesterase suppression is the common approach to …

Graveoline analogs exhibiting selective acetylcholinesterase inhibitory activity as potential lead compounds for the treatment of Alzheimer's disease

Z Li, C Mu, B Wang, J Jin - Molecules, 2016 - mdpi.com
This study designed and synthesized a series of new graveoline analogs on the basis of the
structural characteristics of acetylcholinesterase (AChE) dual-site inhibitors. The activity of …

Synthesis, characterization and in vitro evaluation of substituted N-(2-phenylcyclopropyl)carbamates as acetyl- and butyrylcholinesterase inhibitors

E Horáková, P Drabina, B Brož… - Journal of Enzyme …, 2016 - Taylor & Francis
A serie of O-substituted N-2-phenylcyclopropylcarbamates was prepared and characterized.
These carbamates were tested as inhibitors of acetylcholinesterase (AChE) and …

Substituted benzo [d] isoxazol-3-yl amine compounds as analgesics

B Merla, R Frank, G Bahrenberg, W Schroeder… - US Patent …, 2010 - Google Patents
US7696238B2 - Substituted benzo[d]isoxazol-3-yl amine compounds as analgesics - Google
Patents US7696238B2 - Substituted benzo[d]isoxazol-3-yl amine compounds as analgesics …

An eco-friendly stereoselective synthesis of novel derivatives of indeno [1, 2-b] pyrrole and indeno [1, 2-c] pyridazine

VL Gein, NV Nosova, AN Yankin… - Polycyclic Aromatic …, 2021 - Taylor & Francis
A highly efficient and simple synthesis of a number of pharmaceutically interesting
functionalized indenopirrole derivatives has been developed via the reaction of ninhydrin …