Visible light photocatalysis in the synthesis of pharmaceutically relevant heterocyclic scaffolds

V Srivastava, PK Singh, S Tivari… - Organic Chemistry …, 2022 - pubs.rsc.org
Visible light and photoredox catalysis have emerged as a powerful and long-lasting tool for
organic synthesis, demonstrating the importance of a variety of chemical bond formation …

Multicomponent reactions for the synthesis of pyrroles

V Estevez, M Villacampa, JC Menendez - Chemical Society Reviews, 2010 - pubs.rsc.org
Multicomponent reactions are one of the most interesting concepts in modern synthetic
chemistry and, as shown in this critical review, they provide an attractive entry into pyrrole …

Synthesis and Toxicological Effect of Some New Pyrrole Derivatives as Prospective Insecticidal Agents against the Cotton Leafworm, Spodoptera littoralis (Boisduval)

AA Abdelhamid, KSM Salama, AM Elsayed, MA Gad… - ACS …, 2022 - ACS Publications
Herein, a series of biologically active pyrrole derivatives, namely 2-[(3-cyano-5-aryl-1 H-
pyrrol-2-yl) thio] acetic acids 2a-c, 2-[(2-hydroxyethyl)-thio]-5-aryl-1 H-pyrrole-3-carbonitriles …

The Hantzsch pyrrole synthesis: non-conventional variations and applications of a neglected classical reaction

M Leonardi, V Estévez, M Villacampa… - Synthesis, 2019 - thieme-connect.com
Pyrrole is one of the most important one-ring heterocycles because of its widespread
presence in natural products and unnatural bioactive compounds and drugs in clinical use …

Recent approaches in the organocatalytic synthesis of pyrroles

B Borah, KD Dwivedi, LR Chowhan - RSC advances, 2021 - pubs.rsc.org
Organocatalysis has emerged as one of the most important tools for the synthesis of diverse
structural scaffolds, and has become one of the most important hot topics of current …

Recent advances in metal‐and organocatalyzed asymmetric functionalization of pyrroles

B Borah, KD Dwivedi… - Asian Journal of Organic …, 2021 - Wiley Online Library
The wide occurrence of pyrroles in natural products and pharmaceuticals calls for novel
synthetic methodologies for the efficient synthesis of enantiopure pyrroles. Owing to their …

Design, Synthesis, and Biological Evaluation of N-Carboxyphenylpyrrole Derivatives as Potent HIV Fusion Inhibitors Targeting gp41

K Liu, H Lu, L Hou, Z Qi, C Teixeira… - Journal of medicinal …, 2008 - ACS Publications
On the basis of the structures of small-molecule hits targeting the HIV-1 gp41, N-(4-carboxy-
3-hydroxy) phenyl-2, 5-dimethylpyrrole (2, NB-2), and N-(3-carboxy-4-chloro) phenylpyrrole …

Visible light initiated hantzsch synthesis of 2, 5-diaryl-substituted pyrroles at ambient conditions

T Lei, WQ Liu, J Li, MY Huang, B Yang, QY Meng… - Organic …, 2016 - ACS Publications
Irradiation of a mixture of enamines and α-bromo ketones, with a catalytic amount of Ir (ppy)
3 by visible light (λ= 450 nm), enables the production of various 2, 5-diaryl-substituted …

Development of peptide and small‐molecule HIV‐1 fusion inhibitors that target gp41

L Cai, S Jiang - ChemMedChem, 2010 - Wiley Online Library
It has been 25 years since the development of the first efficient HIV‐1/AIDS treatment.
Scientists now know more about the HIV‐1 infection life cycle, and more than 30 …

Development of indole compounds as small molecule fusion inhibitors targeting HIV-1 glycoprotein-41

G Zhou, D Wu, B Snyder, RG Ptak, H Kaur… - Journal of medicinal …, 2011 - ACS Publications
Nonpeptide inhibition of fusion remains an important goal in anti-HIV research, due to its
potential for low cost prophylaxis or prevention of cell–cell transmission of the virus. We …