Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted
quantitative technique to measure the integrity of tight junction dynamics in cell culture …

Investigation of the toxicity triggered by chemicals on the human brain has traditionally relied
on approaches using rodent in vivo models and in vitro cell models including primary …

Endothelial tight junctions (TJs) regulate the transport of water, ions, and molecules through
the paracellular pathway, serving as an important barrier in blood vessels and maintaining …

Pesticides are omnipresent, and they pose significant environmental and health risks.
Translational studies indicate that acute exposure to high pesticide levels is detrimental, and …

The societal need for new central nervous system (CNS) medicines is substantial, because
of the global increase in life expectancy and the accompanying increase in age-related CNS …

In this work, we describe the fabrication and working of a modular microsystem that
recapitulates the functions of the “Neurovascular Unit”. The microdevice comprised a vertical …

Organophosphorus (OPs) compounds are widely used as insecticides, plasticizers, and fuel
additives. These compounds potently inhibit acetylcholinesterase (AChE), the enzyme that …

Cyanobacteria are capable of producing a wide range of bioactive compounds with many
considered to be toxins. Although there are a number of toxicological outcomes with respect …

Accumulating evidence indicates that chronic exposure to a low level of pesticides found in
diet affects the human gut-microbiota–blood–brain barrier (BBB) axis. This axis describes …

Delivery of most drugs into the central nervous system (CNS) is restricted by the blood–brain
barrier (BBB), which remains a significant bottleneck for development of novel CNS-targeted …