Pharmacological advances in the treatment of age-related macular degeneration

M Gil-Martínez, P Santos-Ramos… - Current medicinal …, 2020 - ingentaconnect.com
Age-related macular degeneration is an acquired degenerative disease that is responsible
for severe loss of vision in elderly people. There are two types: dry age-related macular …

Biomarkers as predictive factors of anti-VEGF response

M Bobadilla, A Pariente, AI Oca, R Peláez… - Biomedicines, 2022 - mdpi.com
Age-related macular degeneration is the main cause of irreversible vision in developed
countries, and intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections are …

Polygenic risk score impact on susceptibility to age-related macular degeneration in polish patients

A Wąsowska, S Teper, E Matczyńska… - Journal of Clinical …, 2022 - mdpi.com
Age-related macular degeneration (AMD) is a common retina degenerative disease with a
complex genetic and environmental background. This study aimed to determine the …

Pharmacogenetic Association between Allelic Variants of the Autophagy-Related Genes and Anti-Vascular Endothelial Growth Factor Treatment Response in …

OS Kozhevnikova, AZ Fursova, AS Derbeneva… - Biomedicines, 2023 - mdpi.com
Background: Age-related macular degeneration (AMD) is the leading cause of late-onset
blindness in elderly. The occurrence and development of AMD is a multifactorial complex …

The Relationship between Complements and Age‐Related Macular Degeneration and Its Pathogenesis

L Chu, C Bi, C Wang, H Zhou - Journal of Ophthalmology, 2024 - Wiley Online Library
Age‐related macular degeneration is a retinal disease that causes permanent loss of central
vision in people over the age of 65. Its pathogenesis may be related to mitochondrial …

Treatment Strategies for Anti-VEGF Resistance in Neovascular Age-Related Macular Degeneration by Targeting Arteriolar Choroidal Neovascularization

Y Fu, Z Zhang, KA Webster, YM Paulus - Biomolecules, 2024 - mdpi.com
Despite extensive use of intravitreal anti-vascular endothelial growth factor (anti-VEGF)
biologics for over a decade, neovascular age-related macular degeneration (nAMD) or …

The association between complement factor H rs1061170 polymorphism and age‐related macular degeneration: A comprehensive meta‐analysis stratified by stage …

A Maugeri, M Barchitta, A Agodi - Acta Ophthalmologica, 2019 - Wiley Online Library
Purpose The strength of association between complement factor H (CFH) rs1061170
polymorphism and age‐related macular degeneration (AMD) differs between AMD subtypes …

[HTML][HTML] Latest development on genetics of common retinal diseases

LJ Chen, ZJ Chen, CP Pang - The Asia-Pacific Journal of …, 2023 - journals.lww.com
Many complex forms of retinal diseases are common and pan-ethnic in occurrence. Among
them, neovascular age-related macular degeneration, polypoidal choroidal vasculopathy …

Nonresponders to ranibizumab anti-VEGF treatment are actually short-term responders: a prospective spectral-domain OCT study

G Bontzos, S Bagheri, L Ioanidi, I Kim, I Datseris… - Ophthalmology …, 2020 - Elsevier
Purpose To investigate the inter-individual variability in duration of anti-vascular endothelial
growth factor (VEGF) treatment effect in neovascular age-related macular degeneration …

Identifying genetic risk factors for diabetic macular edema and the response to treatment

RL Gurung, LM FitzGerald… - Journal of Diabetes …, 2020 - Wiley Online Library
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes
mellitus (DM). DR is complex and the term encompasses several clinical subtypes of …