Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …
functioning associated with the disorder and are not responsive to existing treatments. In this …
Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders
Practitioners frequently use diagnostic criteria to identify children with neurodevelopmental
disorders and to guide intervention decisions. These criteria also provide the organising …
disorders and to guide intervention decisions. These criteria also provide the organising …
Ancestry-inclusive dog genomics challenges popular breed stereotypes
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …
Upper cortical layer–driven network impairment in schizophrenia
Schizophrenia is one of the most widespread and complex mental disorders. To
characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing …
characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing …
The genetics of epilepsy
P Perucca, M Bahlo, SF Berkovic - Annual review of genomics …, 2020 - annualreviews.org
Epilepsy encompasses a group of heterogeneous brain diseases that affect more than 50
million people worldwide. Epilepsy may have discernible structural, infectious, metabolic …
million people worldwide. Epilepsy may have discernible structural, infectious, metabolic …
Genetic variation, brain, and intelligence differences
Individual differences in human intelligence, as assessed using cognitive test scores, have a
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …
Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income
Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing)
multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 …
multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 …
[HTML][HTML] An overview of clustering methods with guidelines for application in mental health research
Cluster analyzes have been widely used in mental health research to decompose inter-
individual heterogeneity by identifying more homogeneous subgroups of individuals …
individual heterogeneity by identifying more homogeneous subgroups of individuals …
[HTML][HTML] The enigmatic fetal subplate compartment forms an early tangential cortical nexus and provides the framework for construction of cortical connectivity
I Kostović - Progress in neurobiology, 2020 - Elsevier
The most prominent transient compartment of the primate fetal cortex is the deep, cell-
sparse, synapse-containing subplate compartment (SPC). The developmental role of the …
sparse, synapse-containing subplate compartment (SPC). The developmental role of the …
[HTML][HTML] Does better education mitigate risky health behavior? A mendelian randomization study
Education and risky health behaviors are strongly negatively correlated. Education may
affect health behaviors by enabling healthier choices through higher disposable income …
affect health behaviors by enabling healthier choices through higher disposable income …