Network approaches to systems biology analysis of complex disease: integrative methods for multi-omics data
In the past decade, significant progress has been made in complex disease research across
multiple omics layers from genome, transcriptome and proteome to metabolome. There is an …
multiple omics layers from genome, transcriptome and proteome to metabolome. There is an …
Genetic insights in Alzheimer's disease
K Bettens, K Sleegers, C Van Broeckhoven - The lancet neurology, 2013 - thelancet.com
In the search for new genes in Alzheimer's disease, classic linkage-based and candidate-
gene-based association studies have been supplanted by exome sequencing, genome …
gene-based association studies have been supplanted by exome sequencing, genome …
[HTML][HTML] Genome-wide association studies of brain imaging phenotypes in UK Biobank
The genetic architecture of brain structure and function is largely unknown. To investigate
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
Effective feature learning and fusion of multimodality data using stage‐wise deep neural network for dementia diagnosis
In this article, the authors aim to maximally utilize multimodality neuroimaging and genetic
data for identifying Alzheimer's disease (AD) and its prodromal status, Mild Cognitive …
data for identifying Alzheimer's disease (AD) and its prodromal status, Mild Cognitive …
Common genetic variation influencing human white matter microstructure
INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
MW Weiner, DP Veitch, PS Aisen, LA Beckett… - Alzheimer's & …, 2013 - Elsevier
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing,
longitudinal, multicenter study designed to develop clinical, imaging, genetic, and …
longitudinal, multicenter study designed to develop clinical, imaging, genetic, and …
Genomic variants, genes, and pathways of Alzheimer's disease: An overview
AC Naj, GD Schellenberg… - American Journal of …, 2017 - Wiley Online Library
Alzheimer's disease (AD)(MIM: 104300) is a highly heritable disease with great complexity
in its genetic contributors, and represents the most common form of dementia. With the …
in its genetic contributors, and represents the most common form of dementia. With the …
Brain imaging genomics: integrated analysis and machine learning
L Shen, PM Thompson - Proceedings of the IEEE, 2019 - ieeexplore.ieee.org
Brain imaging genomics is an emerging data science field, where integrated analysis of
brain imaging and genomics data, often combined with other biomarker, clinical, and …
brain imaging and genomics data, often combined with other biomarker, clinical, and …
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the
investigation of genetic influences on disease onset and trajectory as reflected in structural …
investigation of genetic influences on disease onset and trajectory as reflected in structural …
Impact of the Alzheimer's disease neuroimaging initiative, 2004 to 2014
MW Weiner, DP Veitch, PS Aisen, LA Beckett… - Alzheimer's & …, 2015 - Elsevier
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) was
established in 2004 to facilitate the development of effective treatments for Alzheimer's …
established in 2004 to facilitate the development of effective treatments for Alzheimer's …