568 Hypertension September 2018 prevalence of hypertension with a 2% increase for
every≈ 100 m (≈ 330 ft)-increase in altitude above 3000 mASL (≈ 9800 ft). 16 …

The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the
respiratory, circulatory and nervous systems. The kidneys have an abundant blood supply …

Key points Acclimatization to hypoxia leads to a reduction in plasma volume (PV) that
restores arterial O2 content. Findings from studies investigating the mechanisms underlying …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

Abstract Hypoxia-inducible factor1 (HIF1) plays a pivotal role in ensuring cells adapt to low-
oxygen conditions. Depletion of oxygen, a co-substrate during hydroxylation of prolyl (P402 …

Lowlanders sojourning for more than 1 day at high altitude (HA) experience a reduction in
plasma volume (PV) that increases haemoglobin concentration and thus restores arterial …

Background: Under normal physiological conditions, renal tissue oxygen is tightly regulated.
At high altitude, a physiological challenge is imposed by the decrease in atmospheric …

The present study aims at assessing the effect of hypobaric hypoxia induced renal damage
and associated renal functions in male SD rats. Further, this study was extended to explore …

When ascending to high altitude, it is a rigorous challenge to people who living in the low
altitude area to acclimatize to hypoxic environment. Hypoxia exposure can cause dramatic …

Background Plasma volume status (PVS), a marker of plasma volume expansion and
contraction, is gaining attention in the field of cardiovascular disease because of its role in …