Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases such
as Alzheimer's disease (AD) and Parkinson's disease (PD). However, neuroinflammatory …

In the last two decades, numerous in vitro studies demonstrated that insulin receptors and
theirs downstream pathways are widely distributed throughout the brain. This evidence has …

Disorders of brain glucose metabolism is known to affect brain activity in neurodegenerative
diseases including Alzheimer's disease (AD). Furthermore, recent evidence has shown an …

Central response to insulin is suspected to be defective in Alzheimer's disease. As most
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …

Transgenic rodent models were created to decipher pathogenic mechanisms associated
with Alzheimer's disease (AD), and behavioral apparatuses such as the Morris water maze …

Blood exosomes, which are extracellular vesicles secreted by living cells into the circulating
blood, are regarded as a relatively noninvasive novel tool for monitoring brain physiology …

Insulin resistance as a hallmark of type 2 DM (T2DM) plays a role in dementia by promoting
pathological lesions or enhancing the vulnerability of the brain. Numerous studies related to …

Alzheimer's disease (AD) is a global concern and has become a major public health event
affecting human health. Insulin is a metabolic hormone secreted mainly by the peripheral …

Disrupted myelin and impaired myelin repair have been observed in the brains of patients
and various mouse models of Alzheimer's disease (AD). Clemastine, an H1-antihistamine …

As populations age, prevalence of Alzheimer's disease (AD) is rising. Over 100 years of
research has provided valuable insights into the pathophysiology of the disease, for which …