Polyphenols, also known as phenolic compounds, are chemical substances containing
aromatic rings as well as at least two hydroxyl groups. Natural phenolic compounds exist …

In aging and neurodegenerative diseases, loss of distinct type of neurons characterizes
disease-specific pathological and clinical features, and mitochondria play a pivotal role in …

Cancer and neurodegeneration are different classes of diseases that share the involvement
of mitochondria in their pathogenesis. Whereas the high glycolytic rate (the so-called …

Already in the early 1960s, researchers noted the potential of mitochondria to take up large
amounts of Ca2+. However, the physiological role and the molecular identity of the …

Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

Mitochondria are the respiratory and energetic centers of the cell where multiple intra-and
extracellular signal transduction pathways converge leading to dysfunction of those …

Itraconazole, a clinically used antifungal drug, was found to possess potent antiangiogenic
and anticancer activity that is unique among the azole antifungals. Previous mechanistic …

Anticancer activity of different phenols is documented, but underlying mechanisms remain
elusive. Recently, we have shown that cannabidiol kills the cells of acute lymphoblastic …

Significance: Humans are exposed daily to polyphenols in milligram-to-gram amounts
through dietary consumption of fruits and vegetables. Polyphenols are also available as …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …