Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol,
which has widespread actions throughout the body. Calcitriol regulates numerous cellular …

Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role
in various human cancers. Preclinical research indicates that the active metabolite of vitamin …

Beyond vitamin D (VD) effect on bone homeostasis, numerous physiological functions in
human health have been described for this versatile prohormone. In 2016, 95% of the …

The role of vitamin D in innate immunity is increasingly recognized. Recent work has
identified a number of tissues that express the enzyme 1α-hydroxylase and are able to …

Abstract Knowledge about the ability of vitamin D to function outside its established role in
skeletal homeostasis is not a new phenomenon. Nonclassical immunomodulatory and …

The active form of vitamin D 3, 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), is primarily
known as a key regulator of calcium and phosphate homeostasis. It exerts its biological …

Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

Although ectopic expression of 25-hydroxyvitamin D3-1α-hydroxylase (1α-OHase) has been
recognized for many years, the precise function of this enzyme outside the kidney remains …

Fundamental to understanding the way in which perturbations in the vitamin D endocrine
system can affect human health is an appreciation of the steps involved in the production of …

Purpose Vitamin D has been linked to breast cancer risk, but prognostic effects are
unknown. Such effects are biologically plausible given the presence of vitamin D receptors …