Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics

E Kamma, W Lasisi, C Libner, HS Ng… - Journal of …, 2022 - Springer
There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …

Progressive multiple sclerosis: from pathogenic mechanisms to treatment

J Correale, MI Gaitán, MC Ysrraelit, MP Fiol - Brain, 2017 - academic.oup.com
During the past decades, better understanding of relapsing-remitting multiple sclerosis
disease mechanisms have led to the development of several disease-modifying therapies …

The Nine-Hole Peg Test as a manual dexterity performance measure for multiple sclerosis

P Feys, I Lamers, G Francis, R Benedict… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Impaired manual dexterity is a frequently reported disability in people with multiple sclerosis
(MS) and is increasingly prevalent with worsening disease. While various tests and patient …

PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation

M Linnerbauer, T Beyer, L Nirschl, D Farrenkopf… - Nature …, 2023 - nature.com
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disorder of the central
nervous system (CNS). Current therapies mainly target inflammatory processes during acute …

[HTML][HTML] Brain health: time matters in multiple sclerosis

G Giovannoni, H Butzkueven, S Dhib-Jalbut… - Multiple sclerosis and …, 2016 - Elsevier
Introduction We present international consensus recommendations for improving diagnosis,
management and treatment access in multiple sclerosis (MS). Our vision is that these will be …

Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function

D Ontaneda, AJ Thompson, RJ Fox, JA Cohen - The Lancet, 2017 - thelancet.com
Multiple sclerosis is a major cause of neurological disability, which accrues predominantly
during progressive forms of the disease. Although development of multifocal inflammatory …

Disease‐modifying treatments for multiple sclerosis–a review of approved medications

Ø Torkildsen, KM Myhr, L Bø - European journal of neurology, 2016 - Wiley Online Library
Background and purpose There is still no curative treatment for multiple sclerosis (MS), but
during the last 20 years eight different disease‐modifying compounds have been approved …

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: a randomised, double-blind, placebo-controlled study

A Tourbah, C Lebrun-Frenay, G Edan… - Multiple Sclerosis …, 2016 - journals.sagepub.com
Background: Treatment with MD1003 (high-dose biotin) showed promising results in
progressive multiple sclerosis (MS) in a pilot open-label study. Objective: To confirm the …

Clinical outcome measures in multiple sclerosis: a review

H Inojosa, D Schriefer, T Ziemssen - Autoimmunity reviews, 2020 - Elsevier
A proper clinical evaluation of patients with Multiple Sclerosis (MS) is of great importance to
detect MS progression. It provides important data for physicians on their daily practice as …

Outcome measures in clinical trials for multiple sclerosis

CEP van Munster, BMJ Uitdehaag - CNS drugs, 2017 - Springer
Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …