Among the many neuromodulators used by the mammalian brain to regulate circuit function
and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful …

Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …

Behavioral choices that ignore prior experience promote exploration and unpredictability but
are seemingly at odds with the brain's tendency to use experience to optimize behavioral …

Stimulus-secretion coupling is an essential process in secretory cells in which regulated
exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While …

The idea that astrocytes merely provide structural and trophic support for neurons has been
challenged by the demonstration that astrocytes can regulate neuronal calcium levels …

Protein kinases critically regulate synaptic plasticity in the mammalian hippocampus. Cyclic-
AMP dependent protein kinase (PKA) is a serine–threonine kinase that has been strongly …

Endocannabinoids (eCBs) have emerged as key activity-dependent signals that, by
activating presynaptic cannabinoid receptors (ie, CB1) coupled to G i/o protein, can mediate …

Long-term potentiation (LTP) of synaptic transmission is a form of activity-dependent
synaptic plasticity that exists at most synapses in the nervous system. In the central nervous …

Abstract Adenylyl cyclase types 1 (AC1) and 8 (AC8), the two major calmodulin-stimulated
adenylyl cyclases in the brain, couple NMDA receptor activation to cAMP signaling …

Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain
elusive. We combined pharmacological manipulations of kinase and phosphatase activities …